Temperature-sensitive migration dynamics in neutrophil-differentiated HL-60 cells.

ABSTRACT: Cell migration plays an essential role in wound healing and inflammatory processes inside the human body. Peripheral blood neutrophils, a type of polymorphonuclear leukocyte (PMN), are the first cells to be activated during inflammation and subsequently migrate toward an injured tissue or infection site. This response is dependent on both biochemical signaling and the extracellular environment, one aspect of which includes increased temperature in the tissues surrounding the inflammation site. In our study, we analyzed temperature-dependent neutrophil migration using differentiated HL-60 cells. The migration speed of differentiated HL-60 cells was found to correlate positively with temperature from 30 to 42 °C, with higher temperatures inducing a concomitant increase in cell detachment. Th

SUBMITTER: Khachaturyan G 

PROVIDER: S-EPMC9054779 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature