Topographical relocation of adolescent sleep spindles reveals a new maturational pattern in the human brain.

ABSTRACT: Current theories of human neural development emphasize the posterior-to-anterior pattern of brain maturation. However, this scenario leaves out significant brain areas not directly involved with sensory input and behavioral control. Suggesting the relevance of cortical activity unrelated to sensory stimulation, such as sleep, we investigated adolescent transformations in the topography of sleep spindles. Sleep spindles are known to be involved in neural plasticity and in adults have a bimodal topography: slow spindles are frontally dominant, while fast spindles have a parietal/precuneal origin. The late functional segregation of the precuneus from the frontoparietal network during adolescence suggests that spindle topography might approach the adult state relatively late in development, an

SUBMITTER: Gombos F 

PROVIDER: S-EPMC9054798 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature