New chalcone derivatives: synthesis, antiviral activity and mechanism of action.

ABSTRACT: In this work, twenty-eight chalcone derivatives containing a purine (sulfur) ether moiety were synthesized and their antiviral activities were evaluated. Biological results showed that compound 5d exhibited outstanding inactive activity against tobacco mosaic virus (TMV) in vivo (EC₅₀ = 65.8 μg mL^-1), which is significantly superior to that of ribavirin (EC₅₀ = 154.3 μg mL^-1). Transmission electron microscopy indicated that compound 5d can break the integrity of TMV particles. The results of microscale thermophoresis, fluorescence titration and molecular docking showed that compound 5d had stronger combining affinity (K _a = 1.02 ×10⁵ L mol^-1, K _d = 13.4 μmol L^-1) with TMV

SUBMITTER: Fu Y 

PROVIDER: S-EPMC9055036 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature