Age and sex effects across the blood proteome after ionizing radiation exposure can bias biomarker screening and risk assessment.

ABSTRACT: Molecular biomarkers of ionizing radiation (IR) exposure are a promising new tool in various disciplines: they can give necessary information for adaptive treatment planning in cancer radiotherapy, enable risk projection for radiation-induced survivorship diseases, or facilitate triage and intervention in radiation hazard events. However, radiation biomarker discovery has not yet resolved the most basic features of personalized medicine: age and sex. To overcome this critical bias in biomarker identification, we quantitated age and sex effects and assessed their relevance in the radiation response across the blood proteome. We used high-throughput mass spectrometry on blood plasma collected 24 h after 0.5 Gy total body irradiation (15 MV nominal photon energy) from male and female C57BL/6 

SUBMITTER: Langen B 

PROVIDER: S-EPMC9055069 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature