Luminescent chitosan/carbon dots as an effective nano-drug carrier for neurodegenerative diseases.

ABSTRACT: Designing new materials for effective and targeted drug delivery is pivotal in biomedical research. Herein, we report on the development of a chitosan/carbon dot-based nanocomposite and investigate its efficacy as a carrier for the sustained release of dopamine drug. The carbon dots (CDs) were synthesized from the carbonization of chitosan and were further conjugated with chitosan (CS) to obtain a chitosan/carbon dot (CS/CD) matrix. Dopamine was later encapsulated in the matrix to form a dopamine@CS/CD nanocomposite. The cytotoxicity of IC-21 and SH-SY5Y cell lines was studied at various concentrations of the nanocomposite and the results demonstrate around 97% cell viability. The photoluminescence property revealed the characteristic property of the carbon dots. When excited at 510 nm an

SUBMITTER: Mathew SA 

PROVIDER: S-EPMC9055102 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature