An atomic resolution description of folic acid using solid state NMR measurements.

ABSTRACT: The chemical shift anisotropy tensor and site-specific spin-lattice relaxation time of folic acid were determined by a ¹³C 2DPASS CP-MAS NMR experiment and Torchia CP experiment respectively. The molecular correlation time at various carbon nuclei sites of folic acid was evaluated by assuming that the ¹³C spin-lattice relaxation mechanism is mainly governed by chemical shift anisotropy interaction and hetero-nuclear dipole-dipole coupling. CSA parameters are larger for the carbon nuclei residing at the heteroaromatic ring and aromatic ring, and those attached to double-bonded electronegative oxygen atoms. It is comparatively low for C9, C19, C21, and C22. The molecular correlation time is of the order of 10^-4/10^-5 s for C9, C19, C21 and C22 carbo

SUBMITTER: Ghosh M 

PROVIDER: S-EPMC9055165 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature