Supramolecular interaction of sanguinarine dye with sulfobutylether-β-cyclodextrin: modulation of the photophysical properties and antibacterial activity.

ABSTRACT: The noncovalent host-guest interaction of sanguinarine (SGR), a benzophenanthridine alkaloid, with a nontoxic, water soluble sulfobutylether-β-cyclodextrin (SBE₇βCD, commercially available as Captisol) macrocyclic host has been investigated using ground-state optical absorption, and steady-state and time-resolved fluorescence measurements. The pH-dependent changes in the absorbance of the dye at 327 nm showed a pK _a value of 7.5, which has been shifted to 8.1 in the presence of SBE₇βCD. The changes in the pK _a values, absorption and fluorescence spectra, and fluorescence lifetime values of these two forms of SG with SBE₇βCD indicate complex formation between them. The cationic form shows 3 times higher interaction towards

SUBMITTER: Kadam V 

PROVIDER: S-EPMC9055271 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature