Thiol-ene coupling reaction achievement and monitoring by "in situ" UV irradiation NMR spectroscopy.

ABSTRACT: In this study, the possibilities of a new "in situ" LED UV illumination NMR spectroscopic technique for performing an initiator-free thiol-ene "click" coupling reaction of an allyl-functionalized poly(allyl glycidyl ether) (PAGE) prepolymer with a number of mono- and di-oligo polyethylene glycol (PEG) thiols is demonstrated. The state-of-the-art setup constructed with LEDs as UV light sources that illuminate through optical fibers directly into an NMR testing tube at a fixed wavelength of 365 nm is appropriate for various polymeric materials and biologically active substances. The selected experimental protocol uses a series of periods of irradiation and dark periods, thus providing opportunities to conduct an effective thiol-ene "click" reaction and simultaneously study the kinetic

SUBMITTER: Toncheva-Moncheva N 

PROVIDER: S-EPMC9055274 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature