Novel quercetin and apigenin-acetamide derivatives: design, synthesis, characterization, biological evaluation and molecular docking studies.

ABSTRACT: Flavonoids exhibit essential but limited biological properties which can be enhanced through chemical modifications. In this study, we designed, synthesized, and characterized two novel flavonoid derivatives, quercetin penta-acetamide (1S3) and apigenin tri-acetamide (2S3). These compounds were confirmed using (¹H, ¹³C) NMR, UV-Vis, and FT-IR characterizations. Their interaction with fish sperm DNA (FS-DNA) at physiological pH was investigated by UV-Vis and fluorescence spectrophotometry. The binding constant (K _b) for the UV-Vis experiment was found to be 1.43 ± 0.3 × 10⁴ M^-1 for 1S3 and 2.08 ± 0.2 × 10⁴ M^-1 for 2S3. The binding constants (K _SV) for the fluorescence quenching experiment w

SUBMITTER: Isika D 

PROVIDER: S-EPMC9055277 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature