Pseudo-ginsengenin DQ ameliorated aconitine-induced arrhythmias by influencing Ca²⁺ and K⁺ currents in ventricular myocytes.

ABSTRACT: Pseudo-ginsengenin DQ (PDQ) is the product of the oxidative cyclization of protopanaxadiol. PDQ exhibits various bioactivities, including reversal of multidrug resistance in cancer, renal protective effects against acute nephrotoxicity and attenuating myocardial ischemia injury induced by isoproterenol or ligation of coronary arterials, but its effect on arrhythmias has not been clear until now. Because of the complicated effects of ginseng on the cardiovascular system, it is necessary to investigate whether PDQ affects arrhythmias, which are always concomitant with other cardiac diseases. Aconitine was used to induce arrhythmia in vivo. To understand its electrophysiological fundamental, whole-cell patch-clamp was used to record the L-type calcium current (I _Ca,L)

SUBMITTER: Jin L 

PROVIDER: S-EPMC9055354 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature