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Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine.

ABSTRACT: An effective synthetic method to achieve difluoromethylated oxazolidin-2-imine has been developed via visible-light promoted three-component tandem reaction of aryl allylamines, 2-BTSO2CF2H (BT = Benzothiazole) and isocyanates. This method features mild reaction conditions and good functional group tolerance, and the reaction mechanism was confirmed by experiments and interpreted by quantum chemical calculations.

SUBMITTER: Bao K

PROVIDER: S-EPMC9055360 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Visible-light promoted three-component tandem reaction to synthesize difluoromethylated oxazolidin-2-imine.

Bao Kun K Wei Jun J Yan Huihui H Sheng Rong R

RSC advances 20200709 43

An effective synthetic method to achieve difluoromethylated oxazolidin-2-imine has been developed <i>via</i> visible-light promoted three-component tandem reaction of aryl allylamines, 2-BTSO2CF2H (BT = Benzothiazole) and isocyanates. This method features mild reaction conditions and good functional group tolerance, and the reaction mechanism was confirmed by experiments and interpreted by quantum chemical calculations. ...[more]

PMID: 35518621

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