A mitochondrion-targeted dual-site fluorescent probe for the discriminative detection of SO₃ ^2- and HSO₃ ^- in living HepG-2 cells.

ABSTRACT: Sulfur dioxide, known as an environmental pollutant, produced during industrial productions is also a common food additive that is permitted worldwide. In living organisms, sulfur dioxide forms hydrates of sulfite (SO₂·H₂O), bisulfite (HSO₃ ^-) and sulfite (SO₃ ^2-) under physiological pH conditions; these three exist in a dynamic balance and play a role in maintaining redox balance, further participating in a wide range of physiological and pathological processes. On the basis of the differences in nucleophilicity between SO₃ ^2- and HSO₃ ^-, for the first time, we built a mitochondrion-targeted dual-site fluorescent probe (Mito-CDTH-CHO) based on benzopyran for the highly specific de

SUBMITTER: Deng Z 

PROVIDER: S-EPMC9055423 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature