Fe₃O₄@SiO₂@Au nanoparticles for MRI-guided chemo/NIR photothermal therapy of cancer cells.

ABSTRACT: Novel functionalized (biofunctionalization followed by cisplatin immobilization) Fe₃O₄@SiO₂@Au nanoparticles (NPs) were designed. The encapsulation of Fe₃O₄ cores inside continuous SiO₂ shells preserves their initial structure and strong magnetic properties, while the shell surface can be decorated by small Au NPs, and then cisplatin (cPt) can be successfully immobilized on their surface. The fabricated NPs exhibit very strong T ₂ contrasting properties for magnetic resonance imaging (MRI). The functionalized Fe₃O₄@SiO₂@Au NPs are tested for a potential application in photothermal cancer therapy, which is simulated by irradiation of two colon cancer cell lines (SW480 and SW6

SUBMITTER: Maximenko A 

PROVIDER: S-EPMC9055504 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature