Methodological Approach to Improve Surgical Outcomes of a Pig Subretinal Implantation Model.

ABSTRACT:

Purpose

To improve outcomes for subretinal implantation surgery in pigs.

Methods

Analysis of variables affecting the success of subretinal implantation surgery was performed on videos of 37 surgeries. Ex vivo experiments were conducted to measure intraocular pressure (IOP) and test various prototyped implanters for effectiveness at maintaining IOP.

Results

A video analysis revealed a prolonged sclerotomy open time owing to a combination of uncontrolled bleeding and excessive fluid outflow often resulting in retinal prolapse. Precauterization of the choroid before full-thickness sclerotomy (n = 10) resulted in a reduced incidence of uncontrolled bleeding from 39.1% (9/23) versus 0% (0/10) (P = 0.005) and improved implantation success from 73% to 90%. An ex vivo analysi

SUBMITTER: Mano F 

PROVIDER: S-EPMC9055557 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature