Class 3 semaphorins are transcriptionally regulated by 1,25(OH)₂D₃ in osteoblasts.

ABSTRACT: The vitamin D endocrine system is essential for calcium metabolism and skeletal integrity. 1,25-dihydroxyvitamin D₃ [1,25(OH)₂D₃] regulates bone mineral homeostasis and acts directly on osteoblasts. In the present study we characterized the transcriptional regulation of the class 3 semaphorin (Sema3) gene family by 1,25(OH)₂D₃ in osteoblastic cells. Class 3 semaphorins are secreted proteins that regulate cell growth, morphology and migration, and were recently shown to be involved in bone homeostasis. In ST2, MC3T3-E1 and primary calvarial osteoblast cell cultures we found that all members of the Sema3 gene family were expressed, and that Sema3e and Sema3f were the most strongly induced 1,25(OH)₂D₃ target genes am

SUBMITTER: Ryynanen J 

PROVIDER: S-EPMC9055571 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature