Signature transcriptome analysis of stage specific atherosclerotic plaques of patients.

ABSTRACT:

Background

Inflammation plays an important role in all the stages of atherosclerotic plaque development. The current study aimed at assessing the altered expression of genes functioning in inflammation within the early stage (ES) and advanced stage (AS) atherosclerotic plaques obtained from patients undergoing coronary artery bypass grafting (CABG) surgery and identifying biomarker panel/s that may detect the status of plaque stages using peripheral blood samples.

Methods

A section of ES and AS plaques and normal left internal mammary arteries (LIMA) were obtained from 8 patients undergoing the CABG surgery. Total RNA isolated was analyzed for mRNA and miRNA expression profile by Affymetrix arrays. A significant number of mRNAs was found to be differentially expressed in ES

SUBMITTER: Verma S 

PROVIDER: S-EPMC9055692 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature