NPM2 in malignant peritoneal mesothelioma: from basic tumor biology to clinical medicine.

ABSTRACT:

Background

This review systematically summarizes gene biology features and protein structure of nucleoplasmin2 (NPM2) and the relationship between NPM2 and malignant peritoneal mesothelioma (MPM), in order to explore the molecular pathological mechanism of MPM and explore new therapeutic targets.

Methods

NCBI PubMed database was used for the literature search. NCBI Gene and Protein databases, Ensembl Genome Browser, UniProt, and RCSB PDB database were used for gene and protein review. Three online tools (Consurf, DoGSiteScorer, and ZdockServer), the GEPIA database, and the Cancer Genome Atlas were used to analyze bioinformatics characteristics for NPM2 protein.

Results

The main structural domains of NPM2 protein include the N-terminal core region, acidic region, and m

SUBMITTER: Wu HL 

PROVIDER: S-EPMC9055711 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature