Biomimetic peptide enriched nonwoven scaffolds promote calcium phosphate mineralisation.

ABSTRACT: Cell-free translational strategies are needed to accelerate the repair of mineralised tissues, particularly large bone defects, using minimally invasive approaches. Regenerative bone scaffolds should ideally mimic aspects of the tissue's ECM over multiple length scales and enable surgical handling and fixation during implantation in vivo. Leveraging the knowledge gained with bioactive self-assembling peptides (SAPs) and SAP-enriched electrospun fibres, we presented a cell free approach for promoting mineralisation via apatite deposition and crystal growth, in vitro, of SAP-enriched nonwoven scaffolds. The nonwoven scaffold was made by electrospinning poly(ε-caprolactone) (PCL) in the presence of either peptide P₁₁-4 (Ac-QQRFEWEFEQQ-Am) or P₁₁-8 (A

SUBMITTER: Gharaei R 

PROVIDER: S-EPMC9055731 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature