Assessment of evidence on reported non-genetic risk factors of congenital heart defects: the updated umbrella review.

ABSTRACT:

Background

Congenital heart defect (CHD) is the leading cause of birth defects globally, which results in a great disease burden. It is still imperative to detect the risk factors of CHD. This umbrella review aimed to comprehensively summarize the evidence and grade the evidence of the associations between non-genetic risk factors and CHD.

Methods

Databases including Medline, Embase, Web of Science, Cochrane Library, and four Chinese databases were searched from inception to 18 Jan 2022. The reference lists of systematic reviews (SR) and meta-analyses (MA) were screened, which aimed to explore the non-genetic risk factors of CHD. Subsequently, titles and abstracts of identified records and full texts of selected SR/MA were screened by two independent reviewers based on prede

SUBMITTER: Nie X 

PROVIDER: S-EPMC9055777 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature