Decreased excitability of leptin-sensitive anterior insula pyramidal neurons in a rat model of compulsive food demand.

ABSTRACT: Compulsive eating is an overlapping construct with binge eating that shares many characteristics with substance use disorders. Compulsive eating may impact millions of Americans; presenting in some cases of binge eating disorders, overweight/obesity, and among individuals who have not yet been diagnosed with a recognized eating disorder. To study the behavioral and neurobiological underpinnings of compulsive eating, we employ a published rodent model using cyclic intermittent access to a palatable diet to develop a self-imposed binge-withdrawal cycle. Here, we further validated this model of compulsive eating in female Wistar rats, through the lens of behavioral economic analyses and observed heightened demand intensity, inelasticity and essential value as well as increased food-seeking du

SUBMITTER: Kirson D 

PROVIDER: S-EPMC9055870 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature