Functional extracellular matrix hydrogel modified with MSC-derived small extracellular vesicles for chronic wound healing.

ABSTRACT:

Objectives

Diabetic wound healing remains a global challenge in the clinic and in research. However, the current medical dressings are difficult to meet the demands. The primary goal of this study was to fabricate a functional hydrogel wound dressing that can provide an appropriate microenvironment and supplementation with growth factors to promote skin regeneration and functional restoration in diabetic wounds.

Materials and methods

Small extracellular vesicles (sEVs) were bound to the porcine small intestinal submucosa-based hydrogel material through peptides (SC-Ps-sEVs) to increase the content and achieve a sustained release. NIH3T3 cell was used to evaluate the biocompatibility and the promoting proliferation, migration and adhesion abilities of the SC-Ps-sEVs. EA.hy926

SUBMITTER: Ma S 

PROVIDER: S-EPMC9055911 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature