Modular design and self-assembly of multidomain peptides towards cytocompatible supramolecular cell penetrating nanofibers.

ABSTRACT: The discovery of cell penetrating peptides (CPPs) with unique membrane activity has inspired the design and synthesis of a variety of cell penetrating macromolecules, which offer tremendous opportunity and promise for intracellular delivery of a variety of imaging probes and therapeutics. While cell penetrating macromolecules can be designed and synthesized to have equivalent or even superior cell penetrating activity compared with natural CPPs, most of them suffer from moderate to severe cytotoxicity. Inspired by recent advances in peptide self-assembly and cell penetrating macromolecules, in this work, we demonstrated a new class of peptide assemblies with intrinsic cell penetrating activity and excellent cytocompatibility. Supramolecular assemblies were formed through the self-assembly

SUBMITTER: Yang S 

PROVIDER: S-EPMC9055914 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature