Injectable recombinant block polymer gel for sustained delivery of therapeutic protein in post traumatic osteoarthritis.

ABSTRACT: Protein-based biomaterials offer several advantages over synthetic materials, owing to their unique stimuli-responsive properties, biocompatibility and modular nature. Here, we demonstrate that E₅C, a recombinant protein block polymer, consisting of five repeats of elastin like polypeptide (E) and a coiled-coil domain of cartilage oligomeric matrix protein (C), is capable of forming a porous networked gel at physiological temperature, making it an excellent candidate for injectable biomaterials. Combination of E₅C with Atsttrin, a chondroprotective engineered derivative of anti-inflammatory growth factor progranulin, provides a unique biochemical and biomechanical environment to protect against post-traumatic osteoarthritis (PTOA) onset and progression. E₅C

SUBMITTER: Katyal P 

PROVIDER: S-EPMC9055922 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature