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Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction.

ABSTRACT: A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates.

SUBMITTER: Cao Y

PROVIDER: S-EPMC9055934 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Regioselective O/C phosphorylation of α-chloroketones: a general method for the synthesis of enol phosphates and β-ketophosphonates via Perkow/Arbuzov reaction.

Cao Yuepeng Y Gao Zhenhua Z Li Junchen J Bi Xiaojing X Yuan Ling L Pei Chengxin C Guo Yongbiao Y Shi Enxue E

RSC advances 20200811 49

A regioselective O/C phosphorylation of α-chloroketones with trialkyl phosphites was performed for the first time, which employed solvent-free Perkow reaction and NaI-assisted Arbuzov reaction under mild conditions respectively. Versatile enol phosphates were prepared in good to excellent yields as well as β-ketophosphinates. ...[more]

PMID: 35521103

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