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Water-triggered union of multi-component reactions towards the synthesis of a 4H-chromene hybrid scaffold.

ABSTRACT: An unprecedented union of multi-component reactions to construct pyrazole- and pyranopyrazole-adorned 4H-chromene from simple reactants in water at ambient temperature is reported. This innovative tactic has integrated two distinct four-component reactions (4CRs) that occur transiently to form four new heterocycles via ten covalent bonds in a single step.

SUBMITTER: Kumaravel K

PROVIDER: S-EPMC9055991 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Water-triggered union of multi-component reactions towards the synthesis of a 4H-chromene hybrid scaffold.

Kumaravel Kandhasamy K Rajarathinam Balakrishnan B Vasuki Gnanasambandam G

RSC advances 20200806 49

An unprecedented union of multi-component reactions to construct pyrazole- and pyranopyrazole-adorned 4H-chromene from simple reactants in water at ambient temperature is reported. This innovative tactic has integrated two distinct four-component reactions (4CRs) that occur transiently to form four new heterocycles via ten covalent bonds in a single step. ...[more]

PMID: 35521150

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