Multimodal imaging of hemorrhagic transformation biomarkers in an ischemic stroke model.

ABSTRACT: Hemorrhagic transformation of ischemic stroke has devastating consequences, with high mortality and poor functional outcomes. Animal models of ischemic stroke also demonstrate the potential for hemorrhagic transformation, which complicates biochemical characterization, treatment studies, and hinders poststroke functional outcomes in affected subjects. The incidence of hemorrhagic transformation of ischemic stroke in animal model research is not commonly reported. The postmortem brain of such cases presents a complex milieu of biomarkers due to the presence of healthy cells, regions of varying degrees of ischemia, dead and dying cells, dysregulated metabolites, and blood components (especially reactive Fe species released from lysed erythrocytes). To improve the characterization of hemorrha

SUBMITTER: Pushie MJ 

PROVIDER: S-EPMC9056027 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature