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Deciphering the Pharmacological Potentials of Methanol Extract of Sterculia foetida Seeds Using Experimental and Computational Approaches.

ABSTRACT: The edible herb Sterculia foetida L. has potential nutraceutical and medicinal effects. The present study is performed to assess the possible antidiabetic, neuropharmacological, and antidiarrheal activity of the methanolic extract of S. foetida seeds (MESF) through in vitro, in vivo, and in silico approaches. When compared to standard acarbose, the results of the antidiabetic study provided strong proof that the glucose level in the MESF was gradually decreased by inhibiting the function of α-amylase enzymes. The sedative potential of MESF (200 and 400 mg/kg) was determined by employing open field, hole cross, and thiopental sodium-induced sleeping time tests, which revealed significant reductions in locomotor performance and increased sleep duration following MESF treatment. In addition, mice treated with MESF exhibited superior exploration during elevated plus maze and hole board tests. MESF also showed good antidiarrheal activity in castor oil-induced diarrhea and intestinal motility tests. Previously isolated compounds (captan, 1-azuleneethanol, acetate, and tetraconazole) exhibited good binding affinity in docking studies and drug-likeliness properties in absorption, distribution, metabolism, excretion/toxicity (ADME/T), and toxicological studies. Collectively, these results indicate the bioactivity of S. foetida, which represents a potential candidate in the food and pharmaceutical industries.

SUBMITTER: Alam N

PROVIDER: S-EPMC9056218 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature

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Deciphering the Pharmacological Potentials of Methanol Extract of Sterculia foetida Seeds Using Experimental and Computational Approaches.

Alam Najmul N Banu Naureen N Alam Nobi Ul NU Ruman Umme U Khan Zidan Z Ibn Aziz Md Arfin MA Barua Niloy N Chy Farhana Jahan FJ Jahan Afrin A Juthy Tamalika Sarker TS Nassan Mohamed A MA El-Bahy Salah M SM Abdel-Rahman Mohamed Amany A Sayeed Mohammed Aktar MA Emran Talha Bin TB

Evidence-based complementary and alternative medicine : eCAM 20220423

The edible herb Sterculia foetida L. has potential nutraceutical and medicinal effects. The present study is performed to assess the possible antidiabetic, neuropharmacological, and antidiarrheal activity of the methanolic extract of S. foetida seeds (MESF) through in vitro, in vivo, and in silico approaches. When compared to standard acarbose, the results of the antidiabetic study provided strong proof that the glucose level in the MESF was gradually de ...[more]

PMID: 35502174

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Deciphering the Pharmacological Potentials of Methanol Extract of Sterculia foetida Seeds Using Experimental and Computational Approaches.

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Deciphering the Pharmacological Potentials of Methanol Extract of <i>Sterculia foetida</i> Seeds Using Experimental and Computational Approaches.

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