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A [3 + 2] cycloaddition/C-arylation of isatin N,N'-cyclic azomethine imine 1,3-dipole with arynes.

ABSTRACT: A [3 + 2] annulation/C-arylation of isatin N,N'-cyclic azomethine imine 1,3-dipole 1 with in situ generated arynes has been established for the synthesis of 3,3-disubstituted oxindole scaffolds. These highly functionalized scaffolds were assembled in moderate yields (up to 85% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery.

SUBMITTER: Jin Q

PROVIDER: S-EPMC9056323 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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A [3 + 2] cycloaddition/C-arylation of isatin N,N'-cyclic azomethine imine 1,3-dipole with arynes.

Jin Qiaomei Q Zhang Dongjian D Zhang Jian J

RSC advances 20200819 51

A [3 + 2] annulation/C-arylation of isatin N,N'-cyclic azomethine imine 1,3-dipole 1 with in situ generated arynes has been established for the synthesis of 3,3-disubstituted oxindole scaffolds. These highly functionalized scaffolds were assembled in moderate yields (up to 85% yield). The novel spirooxindole scaffolds displayed moderate antitumor activities, which represented promising lead compounds for antitumor drug discovery. ...[more]

PMID: 35516012

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