New marine-derived indolymethyl pyrazinoquinazoline alkaloids with promising antimicrobial profiles.

ABSTRACT: Due to the emergence of multidrug-resistant pathogenic microorganisms, the search for novel antimicrobials is urgent. Inspired by marine alkaloids, a series of indolomethyl pyrazino [1,2-b]quinazoline-3,6-diones was prepared using a one-pot microwave-assisted multicomponent polycondensation of amino acids. The compounds were evaluated for their antimicrobial activity against a panel of nine bacterial strains and five fungal strains. Compounds 26 and 27 were the most effective against Staphylococcus aureus ATCC 29213 reference strain with MIC values of 4 μg mL^-1, and a methicillin-resistant Staphylococcus aureus (MRSA) isolate with MIC values of 8 μg mL^-1. It was possible to infer that enantiomer (-)-26 was responsible for the antibacterial activit

SUBMITTER: Long S 

PROVIDER: S-EPMC9056383 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature