Lutetium-containing sinoporphyrin sodium: a water-soluble photosensitizer with balanced fluorescence and phosphorescence for ratiometric oxygen sensing.

ABSTRACT: Development of a photosensitizer for ratiometric O₂ sensing is desirable for the precise treatment of cancer by photodynamic therapy. Herein, lutetium(iii)-containing sinoporphyrin sodium (Lu-DVDMS) was designed as a phosphorescent photosensitizer to balance phosphorescence and fluorescence emissions for ratiometric O₂ sensing. Lu-DVDMS exhibited high water solubility, chemical stability, photostability, photosensitivity, and singlet-oxygen quantum yield of 0.23 ± 0.06. The phosphorescence and fluorescence quantum yields of Lu-DVDMS were 0.33 and 0.32%, respectively. Compared with the phosphorescence-to-fluorescence ratio (R) of gadolinium-DVDMS (Gd-DVDMS), which was >10, that of Lu-DVDMS was ∼1, facilitating ratiometric O₂ sensing. The relatively we

SUBMITTER: Zang L 

PROVIDER: S-EPMC9056626 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature