Retracted Article: Functional disruption of staphylococcal accessory regulator A from Staphylococcus aureus by silver ions.

ABSTRACT: Silver ions (Ag⁺) have attracted profound attention due to their broad-spectrum antimicrobial activities. Although the antibacterial properties of silver have been well known for many centuries, its mechanism of action is not fully understood and its protein targets remain largely unknown. Staphylococcus aureus (S. aureus) is the leading cause of hospital- and community-acquired infections. Staphylococcal accessory regulator protein family from Staphylococcus aureus has been found to play vital roles in the regulation of virulence genes. In this study, we demonstrated that silver ions bind to the staphylococcal accessory regulator A (SarA) of S. aureus via its cysteine residues. Importantly, binding of silver ions leads to functional disruption of Sar

SUBMITTER: Liao X 

PROVIDER: S-EPMC9056660 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature