Near-infrared-IIb probe affords ultrahigh contrast inflammation imaging.

ABSTRACT: Deep tissue imaging in the near-infrared II (NIR-II) window with significantly reduced tissue autofluorescence and scattering provides an important modality to visualize various biological events. Current commercially used contrast agents in the near-infrared spectrum suffer from severe photobleaching, high tissue scattering, and background signals, hampering high-quality in vivo bioimaging, particularly in small animals. Here, we applied a NIR-IIb quantum dot (QD) probe with greatly suppressed photon scattering and zero autofluorescence to map inflammatory processes. Two-layer surface modification by a combination of amphiphilic polymer and mixed linear and multi-armed polyethylene glycol chains prolonged probe circulation in vivo and improved its accumulation in the inflamm

SUBMITTER: Hua C 

PROVIDER: S-EPMC9056738 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature