Synthesis and characterization of a hyaluronic acid-based hydrogel with antioxidative and thermosensitive properties.

ABSTRACT: Peripheral arterial disease (PAD) is initiated by progressive atherosclerotic blockages of the arteries supplying the lower extremities. The most common presentation of PAD is claudication (leg pain and severe walking limitation), with many patients progressing to limb threatening ischemia and amputation. Biomaterial approaches are just beginning to be explored in the therapy of PAD with different materials now being evaluated for the delivery of cells or growth factors in animal models of PAD. A biomaterial matrix optimized for minimally invasive injection in the ischemic leg muscles of patients with PAD is urgently needed. There are several important requirements for optimal delivery, retention, and performance of a biomaterial matrix in the mechanically, histologically, and biochemicall

SUBMITTER: Chen M 

PROVIDER: S-EPMC9056774 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature