PH-Tolerant giant vesicles composed of cationic lipids with imine linkages and oleic acids.

ABSTRACT: Giant vesicles (GVs) have attracted attention as functional materials because they can encapsulate both hydrophilic and hydrophobic compounds. For next generation functional GVs, both tolerance and stimuli-sensitivity are needed. So far, vesicles tolerant to acidic or basic conditions were generated using a mixture of cationic lipids and fatty acids. Here, to create functional GVs that are tolerant to a wide pH range but sensitively respond at below a specific pH, the behaviour of GVs composed of a cationic lipid with an imine bond and oleic acid was investigated. Even though the GVs prepared by the film swelling method were tolerant to strongly acidic conditions, GVs without oleic acid gradually shrank, accompanied by the generation of oil droplets at the same pH. ¹H NMR analys

SUBMITTER: Sawada D 

PROVIDER: S-EPMC9056790 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature