Synthesis and biological activities of novel trifluoromethylpyridine amide derivatives containing sulfur moieties.

ABSTRACT: A series of trifluoromethylpyridine amide derivatives containing sulfur moieties (thioether, sulfone and sulfoxide) was designed and synthesized. Their antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo), Ralstonia solanacearum (R. solanacearum) and insecticidal activities against P. xylostella were evaluated. Notably, the half-maximal effective concentration (EC₅₀) value of sulfone-containing compound F10 is 83 mg L^-1 against Xoo, which is better than that of commercial thiodiazole copper (97 mg L^-1) and bismerthiazol (112 mg L^-1). Thioether-containing compounds E1, E3, E5, E6, E10, E11 and E13 showed much higher activities against R. solanacearum with the EC₅₀ v

SUBMITTER: Guo SX 

PROVIDER: S-EPMC9056882 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature