Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework.

ABSTRACT: COVID-19 has been declared as a global health emergency and exposed the world to a deadly virus, which has dramatically changed the lives of humans for an unknown period of time. In the battleground with the virus, we have employed an immunoinformatics framework to design a robust vaccine as an insurance plan for the future. The pathogenic sequence with cryptic epitope taken from patients in Wuhan, China, was harnessed to design a promiscuous cytotoxic T-lymphocyte, helper T-lymphocyte, and B-cell epitope based subunit vaccine, engineered with adjuvants and conformational linkers. The reported vaccine has high antigenicity and immunogenicity profiles with potential TAP affinity, which ensures elevated antigen processing capability. It has strong binding with major histocompatibility comple

SUBMITTER: Kumar N 

PROVIDER: S-EPMC9056885 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature