Alcohol amine-catalyzed CO₂ conversion for the synthesis of quinazoline-2,4-(1H,3H)-dione in water.

ABSTRACT: The conversion of CO₂ to high value-added chemicals in water using environment-friendly and cost-effective catalysts is a very significant topic. In this work, a green method for the conversion of CO₂ catalyzed by alcohol amines has been developed. Alcohol amines showed considerable activating ability to CO₂ in the cyclization with 2-aminobenzonitrile to quinazoline-2,4(1H,3H)-dione in water. Notably, when diethanolamine (DEA) was used as the catalyst, 94% yield of quinazoline-2,4-(1H,3H)-dione could be achieved. A plausible mechanism has been proposed based on the ¹H NMR, FT-IR analysis and DFT calculation. The excellent catalytic performance is attributed to the combined effect of both the secondary amine and hydroxy

SUBMITTER: Sheng ZZ 

PROVIDER: S-EPMC9056919 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature