MRI contrast enhancement of liver pre-neoplasia using iron-tannic nanoparticles.

ABSTRACT: The most challenging part of liver cancer detection is finding it in the very early stages. It has been argued that liver preneoplasia is found at the very earliest stages of liver cancer. The presence of a lesion is closely related to the development of HCC. We report herein a new class of iron-based T₁ MRI contrast agents which are nanoparticles of iron-tannic complexes (so-called Fe-TA NPs) that can be used for detecting liver preneoplasia. Preliminary assessment of their toxicity in healthy rats provides suitable imaging dose ranges with acceptable toxicity. In diethylnitrosamine (DEN) induced rats, it is shown that Fe-TA NPs are capable of enhancing MRI signals in rat livers having pre-neoplastic lesions within 60 minutes post-injection. The enhancement efficacy is strongly

SUBMITTER: Phatruengdet T 

PROVIDER: S-EPMC9056925 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature