LiCl-promoted amination of β-methoxy amides (γ-lactones).

ABSTRACT: An efficient and mild method has been developed for the amination of β-methoxy amides (γ-lactones) including natural products michelolide, costunolide and parthenolide derivatives by using lithium chloride in good yields. This reaction is applicable to a wide range of substrates with good functional group tolerance. Mechanism studies show that the reactions undergo a LiCl promoted MeOH elimination from the substrates to form the corresponding α,β-unsaturated intermediates followed by the Michael addition of amines.

SUBMITTER: Zhao R 

PROVIDER: S-EPMC9056935 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature