LncExACT1 and DCHS2 Regulate Physiological and Pathological Cardiac Growth.

ABSTRACT:

Background

The heart grows in response to pathological and physiological stimuli. The former often precedes cardiomyocyte loss and heart failure; the latter paradoxically protects the heart and enhances cardiomyogenesis. The mechanisms underlying these differences remain incompletely understood. Although long noncoding RNAs (lncRNAs) are important in cardiac development and disease, less is known about their roles in physiological hypertrophy or cardiomyogenesis.

Methods

RNA sequencing was applied to hearts from mice after 8 weeks of voluntary exercise-induced physiological hypertrophy and cardiomyogenesis or transverse aortic constriction for 2 or 8 weeks to induce pathological hypertrophy or heart failure. The top lncRNA candidate was overexpressed in hearts with adeno-ass

SUBMITTER: Li H 

PROVIDER: S-EPMC9056949 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature