Functionalization of MOF-5 with mono-substituents: effects on drug delivery behavior.

ABSTRACT: Metal organic frameworks (MOFs) are widely used in drug carrier research due to their tunability. The properties of MOFs can be adjusted through incorporation of mono-substituents to obtain pharmaceutical carriers with excellent properties. In this study, different functional groups of -NH₂, -CH₃, -Br, -OH and -CH₂[double bond, length as m-dash]CH are connected to MOF-5 to analyse the effect of mono-substituent incorporation on drug delivery properties. The resulting MOFs have similar structures, except for Br-MOF. The pore size of this series of MOFs ranges from 1.04 nm to 1.10 nm. Using oridonin (ORI) as a model drug, introduction of the functional groups appears to have a significant effect on the drug delivery performance of the MOFs. The IRMOFs can be

SUBMITTER: Cai M 

PROVIDER: S-EPMC9057024 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature