Surface refined Au^Quercetin nanoconjugate stimulates dermal cell migration: possible implication in wound healing.

ABSTRACT: Refining nutraceutical conjugated metal nanoparticles (NPs) and understanding their interactions with the cellular micro-environment is necessary for their application in nanomedicine. In the present experiment, we studied the effect of quercetin functionalized gold nanoparticles (Au^QurNP) on skin fibroblast and keratinocyte cell migration. Spherical shaped Au^QurNPs of 47 nm in size were formed due to the interaction of hydroxyl and carbonyl groups of quercetin with Au atoms as revealed by incremental algorithm-based analysis. Au^QurNP containing up to 5 μg l^-1 of Au with quercetin (5.2 ± 1.6 ng ml^-1) was least toxic to fibroblasts. Au^QurNP effectively reduced the generation of intracellular ROS (up to 63%) through free-radic

SUBMITTER: H M 

PROVIDER: S-EPMC9057138 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature