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New cytotoxic natural products from the marine sponge-derived fungus Pestalotiopsis sp. by epigenetic modification.

ABSTRACT: Four new polyketide derivatives, pestalotiopols A-D (1-4), together with seven known compounds (5-11), were isolated from a chemical-epigenetic culture of Pestalotiopsis sp. The structures and absolute configurations of the new compounds (1-4) were determined by spectroscopic analyses, Mo₂-induced CD, and electronic circular dichroism (ECD) calculations. All the isolated compounds (1-11) were tested for their cytotoxic activities. Among these compounds, compounds 1, 2, 6 and 7 exhibited cytotoxicity against four human cancer cell lines with IC₅₀ values of 16.5-56.5 μM. The structure-activity relationships of compounds (1-11) were examined. The results indicated that both the diol system of the side chain and the aldehyde group might contribute to the cytotoxic activity. The possible biosynthetic pathways for compounds (1-4) were also postulated.

SUBMITTER: Lei H

PROVIDER: S-EPMC9057218 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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New cytotoxic natural products from the marine sponge-derived fungus Pestalotiopsis sp. by epigenetic modification.

Lei Hui H Zhang Dan D Ding Nan N Chen Siwei S Song Can C Luo Yu Y Fu Xiujuan X Bi Xiaoxu X Niu Hong H Niu Hong H

RSC advances 20201014 62

Four new polyketide derivatives, pestalotiopols A-D (1-4), together with seven known compounds (5-11), were isolated from a chemical-epigenetic culture of Pestalotiopsis sp. The structures and absolute configurations of the new compounds (1-4) were determined by spectroscopic analyses, Mo2-induced CD, and electronic circular dichroism (ECD) calculations. All the isolated compounds (1-11) were tested for their cytotoxic activities. Among these compounds, compounds 1, 2, 6 and 7 ...[more]

PMID: 35515153

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