Synthesis of aryl azide chain-end functionalized N-linked glycan polymers and their photo-labelling of specific protein.

ABSTRACT: We report a straightforward synthesis of aryl azide chain-end functionalized N-linked glycan polymers and its application for affinity-assisted photo-labelling of specific protein. The aryl azide chain-end functionalized N-glycan polymers, including N-galactosyl, N-glucosyl, and N-lactosyl polymer, were synthesized from free glycan via glycosylamine intermediates followed by acrylation and polymerization via cyanoxyl-mediated free radical polymerization (CMFRP) in a one-pot fashion. The aryl azide chain-end functionalized N-glycan polymers were characterized by ¹H NMR and IR spectroscopy. The affinity-assisted photo-labeling capabilities of the aryl azide N-glycan polymers were demonstrated with aryl azide N-l

SUBMITTER: Chan KK 

PROVIDER: S-EPMC9057295 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature