Structural and conformational changes induced by missense variants in the zinc finger domains of GATA3 involved in breast cancer.

ABSTRACT: Breast cancer (BC) is the main cancer in women having multiple receptor based tumour subtypes. Large scale genome sequencing studies of BC have identified several genes among which GATA3 is reported as a highly mutated gene followed by TP53 and PIK3CA. GATA3 is a crucial transcription factor, and was initially identified as a DNA-binding protein involved in the regulation of immune cell functions. Different missense mutations in the region of the DNA-binding domain of GATA3 are associated with BC and other neoplastic disorders. In this study, computational based approaches have been exploited to reveal associations of various mutations on structure, stability, conformation and function of GATA3. Our findings have suggested that, all analysed missense mutations were deleterious and highly p

SUBMITTER: Kumar R 

PROVIDER: S-EPMC9057444 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature