Sex-Specific Genetic Associations for Barrett's Esophagus and Esophageal Adenocarcinoma.

ABSTRACT:

Background & aims

Esophageal adenocarcinoma (EA) and its premalignant lesion, Barrett's esophagus (BE), are characterized by a strong and yet unexplained male predominance (with a male-to-female ratio in EA incidence of up to 6:1). Genome-wide association studies (GWAS) have identified more than 20 susceptibility loci for these conditions. However, potential sex differences in genetic associations with BE/EA remain largely unexplored.

Methods

Given strong genetic overlap, BE and EA cases were combined into a single case group for analysis. These were compared with population-based controls. We performed sex-specific GWAS of BE/EA in 3 separate studies and then used fixed-effects meta-analysis to provide summary estimates for >9 million variants for male and female individual

SUBMITTER: Dong J 

PROVIDER: S-EPMC9057456 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature