Homo-condensation of acetophenones toward imidazothiones.

ABSTRACT: Direct synthesis of imidazothiones from simple, commercial substrates is not known. We report a method for the condensation of acetophenones, elemental sulfur, and ammonium acetate as a nitrogen source to obtain the hitherto challenging five-membered heterocycles. Functionalities such as halogen, trifluoromethyl, cyano, methylthio, and heteroaryl groups were well tolerated.

SUBMITTER: Pham PH 

PROVIDER: S-EPMC9057481 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature