Clinical Utility of Next-Generation Flow-Based Minimal Residual Disease Assessment in Patients with Multiple Myeloma.

ABSTRACT:

Background

Minimal residual disease (MRD) is an important prognostic factor for evaluating a deeper treatment response in patients with multiple myeloma (MM). We evaluated the clinical utility of next-generation flow (NGF)-based MRD assessment in a heterogeneous MM patient population.

Methods

Patients with suspected morphological remission after or during MM treatment were prospectively enrolled. In total, 108 bone marrow samples from 90 patients were analyzed using NGF-based MRD assessment according to the EuroFlow protocol, and progression-free survival (PFS) was evaluated according to the International Myeloma Working Group response status, cytogenetic risk, and MRD status.

Results

The overall MRD-positive rate was 31.5% (34/108 samples), and MRD-positive patients

SUBMITTER: Kim HY 

PROVIDER: S-EPMC9057816 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature