Functionalized heterocycle-appended porphyrins: catalysis matters.

ABSTRACT: The scope and limitations of the condensation of labile 2,3-diaminoporphyrin derivatives with aromatic aldehydes to provide functionalized imidazole- and pyrazine-appended porphyrins were investigated in detail. The presence of an acidic catalyst in the reaction was found to be a tool that allows the reaction path to be switched. The influence of the electronic origin of the substituents in the carbonyl components of the condensation on the yields and selectivity of the reaction was revealed. Metal-promoted cross-coupling transformations were found to be convenient for the further targeted construction of functional derivatives based on the prepared bromo-substituted pyrazinoporphyrins. Overall, these strategies provide a versatile technique for the elaboration of a variety of functionaliz

SUBMITTER: Abdulaeva IA 

PROVIDER: S-EPMC9057987 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature