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Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives.

ABSTRACT: A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level.

SUBMITTER: Cheng C

PROVIDER: S-EPMC9058008 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives.

Cheng Cheng C Li Ying-Xian YX Jia Xue-Min XM Zhang Ji-Quan JQ Zhao Yong-Long YL Feng Wei W Tang Lei L Yang Yuan-Yong YY

RSC advances 20201125 70

A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level. ...[more]

PMID: 35514906

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