Enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives.

ABSTRACT: A mild and efficient enantioselective amination of 4-alkylisoquinoline-1,3(2H,4H)-dione derivatives was established, which is compatible with a broad range of substrates and delivers the final products in excellent yields (up to 99%) and ee values (up to 99%) with low catalyst loading (down to 1 mol%). The synthetic potential of this methodology was also demonstrated in the gram scale level.

SUBMITTER: Cheng C 

PROVIDER: S-EPMC9058008 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature